Invention Grant
- Patent Title: Adeno-associated virus complex with improved expression of RUNX3 gene and uses for preventing or treating KRAS mutated lung cancer
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Application No.: US18190561Application Date: 2023-03-27
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Publication No.: US11767541B1Publication Date: 2023-09-26
- Inventor: Suk Chul Bae , You Soub Lee , Xinzi Chi , Ja Yeol Lee
- Applicant: GENECRAFT INC.
- Applicant Address: KR Cheongju-si
- Assignee: GENECRAFT, INC.
- Current Assignee: GENECRAFT, INC.
- Current Assignee Address: KR Cheongju-si
- Agency: Crowell & Moring LLC
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C12N15/86 ; A61P35/00
Abstract:
Provided is an adeno-associated virus (AAV) complex for expression of an RUNX3 gene including an asymmetrically modified inverted terminal repeat (ITR). The AAV complex has asymmetric ITRs in which one of the two ITRs is modified, thereby increasing self-replication efficiency in host cells and increasing expression efficiency of a delivered gene, and therefore, compared to existing AAV complexes, the AAV complex has an advantage of improved productivity and gene expression efficiency.
Information query
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