A facade panel conditioning system for installation on a new or existing building is disclosed. The system includes modular panels, a structural anchor, hydronic piping, and ductwork. The panels attach to each other around the exterior of the building forming an insulated shell. The anchor attaches the panels to the building structure forming an air cavity between each individual panel and the exterior. The hydronic piping transfers heat to the air cavity and individual units of the building. The ductwork delivers ventilated air and exhaust air to the air cavity and individual units. The hydronic piping of a panel connects to the hydronic piping of an adjacent panel forming a hydronic piping system that distributes heat or cool throughout the shell. The air duct of a panel connects to the air duct of an adjacent panel forming an air duct ventilation system that distributes air throughout the shell.