The present application discloses a method and an apparatus for processing transaction requests in a blockchain, a device and a medium, which relate to blockchain technologies. The method includes: aggregating transaction requests to be selected with dependency relationships in a blockchain network to obtain at least one transaction request set; determining candidate factor intervals to which the transaction request set belongs, where the factor interval is used to evaluate a probability that the transaction request set participates in a block generation process; and selecting a current target factor interval from the candidate factor intervals, and selecting a current target transaction request set participating in the block generation process from candidate transaction request sets corresponding to the current target factor interval.