A system and computer-implemented method for analysing or monitoring a subject, the method comprising: identifying one or more objects of interest that have been segmented from a first image comprising any of a baseline scan, a follow-up scan or a reference image of the subject; identifying predefined landmarks of the objects; determining reference morphometries pertaining to the objects by performing morphometrics on the objects by reference to the landmarks; selecting one or more regions of interest (ROIs) from the objects according to the reference morphometries, comprising identifying respective locations of the ROIs relative to the reference morphometries; performing a first analysis of the one or more ROIs; performing at least one corresponding second analysis of the one or more ROIs in respectively at least one second image comprising any other of a baseline scan, a follow-up scan or a reference image; and generating a comparison of one or more results of the first analysis and one or more corresponding results of the second analysis.