An LED display screen and a manufacturing method therefor. The method comprises: presetting a temporary jig consisting of a first substrate (1) having a plurality of placement grooves, and a cover plate (3), and alternately placing R, G, and B-color LEDs in the placement grooves (2) by means of placement groove inlets (4); attaching a side cover to the temporary jig, and replacing the cover plate with an LED substrate and attaching the LEDs to the LED substrate; removing the first substrate and the side cover and sealing the LED substrate, and connecting a circuit board to the LED substrate, so as to obtain the LED display screen.