Invention Grant
- Patent Title: Eye drops in form of solution comprising benzopyran derivative or pharmaceutically acceptable salt thereof
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Application No.: US16975695Application Date: 2019-02-18
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Publication No.: US11771647B2Publication Date: 2023-10-03
- Inventor: Dong-Yeop Shin , Hu-Seong Kim , Geun-Hyeog Lee , Kyung-Joon Kim , Yun-Seok Cho , Mi-Jin O , Mi-Jung Kim
- Applicant: HANLIM PHARMACEUTICAL CO., LTD.
- Applicant Address: KR Yongin-si
- Assignee: HANLIM PHARMACEUTICAL CO., LTD.
- Current Assignee: HANLIM PHARMACEUTICAL CO., LTD.
- Current Assignee Address: KR Yongin-si
- Agency: Vorys, Sater, Seymour and Pease LLP
- Agent Mih Suhh Koh
- Priority: KR 20180024470 2018.02.28
- International Application: PCT/KR2019/001894 2019.02.18
- International Announcement: WO2019/168289A 2019.09.06
- Date entered country: 2020-08-25
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61P27/02 ; A61K9/08 ; A61K31/4178 ; A61K47/02 ; A61K47/10 ; A61K47/18

Abstract:
The present invention provides an eye drop formulation in the form of a solution, comprising (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran or a pharmaceutically acceptable salt thereof; propylene glycol as a stabilizing agent; and a pH controlling agent in an aqueous medium, wherein the eye drop formulation has a pH ranging from 4.0 to 5.0. The eye drop formulation of the present invention can contain (2R,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(1H-imidazol-2-ylmethyl)amino]-3-hydroxy-2-methyl-2-dimethoxymethyl-3,4-dihydro-2H-1-benzopyran or a pharmaceutically acceptable salt thereof in a high concentration; and has an excellent stability. In addition, the pharmaceutical product for preventing or treating macular degeneration according to the present invention can be stored for extended periods.
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