Invention Grant
- Patent Title: Polypeptide compositions comprising spacers
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Application No.: US16163233Application Date: 2018-10-17
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Publication No.: US11771718B2Publication Date: 2023-10-03
- Inventor: Rutul R. Shah
- Applicant: Intrexon Corporation
- Applicant Address: US VA Blacksburg
- Assignee: PRECIGEN, INC.
- Current Assignee: PRECIGEN, INC.
- Current Assignee Address: US MD Germantown
- Agency: Barnes & Thornburg LLP
- Agent Gene J. Yao
- Main IPC: A61K35/17
- IPC: A61K35/17 ; C07K16/28 ; C07K14/705 ; C07K14/725 ; C12N15/62 ; C12N15/85 ; A61P37/06 ; A61P35/00 ; C12N15/113

Abstract:
Disclosed herein are methods and compositions including antigen-binding polypeptides comprising a stalk region and a stalk extension region. In some cases, the antigen-binding compositions comprising the stalk extension region has increased expression on a cell surface and, in some cases, has increased antigen-binding efficiency. A subject antigen binding polypeptide can be a chimeric antigen receptor (CAR).
Public/Granted literature
- US20190111080A1 POLYPEPTIDE COMPOSITIONS COMPRISING SPACERS Public/Granted day:2019-04-18
Information query
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