Invention Grant
- Patent Title: Antagonistic CD40 monoclonal antibodies and uses thereof
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Application No.: US17588518Application Date: 2022-01-31
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Publication No.: US11773178B2Publication Date: 2023-10-03
- Inventor: Aaron Yamniuk , Mary Struthers , Stanley R. Krystek, Jr. , Akbar Nayeem , Ginger Rakestraw
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agency: BANNER & WITCOFF, LTD.
- The original application number of the division: US16686596 2019.11.18
- Main IPC: C12N15/63
- IPC: C12N15/63 ; C07K16/28 ; A61K39/395 ; A61K47/68 ; C07K16/46 ; A61P37/00 ; A61K45/06 ; A61K39/00 ; C07K14/705

Abstract:
The disclosure provides for antibodies that bind CD40, including a humanized antibody. The antibodies bind CD40 and do not exhibit CD40 agonist activity. The antibodies may comprise a modified IgG1 Fc domain, and exhibit minimal activation of immature dendritic cells. Compositions comprising antibodies, methods of use for treatment of diseases involving CD40 activity, and use in the preparation of a medicament for treatment of a disease involving CD40 activity are provided.
Public/Granted literature
- US20220153856A1 ANTAGONISTIC CD40 MONOCLONAL ANTIBODIES AND USES THEREOF Public/Granted day:2022-05-19
Information query
IPC分类: