Methods, apparatus, and processor-readable storage media for automated configuration determinations for data center devices using artificial intelligence are provided herein. An example computer-implemented method includes obtaining input information pertaining to one or more device-related changes to a data center; obtaining telemetry data attributed to one or more devices in the data center; determining one or more device configurations for implementation in at least one device in the data center in connection with the one or more device-related changes by processing the input information and the obtained telemetry data using one or more artificial intelligence techniques; and performing at least one automated action based at least in part on the one or more determined device configurations.