An interleaved antenna array configuration in a radio node is disclosed. The antenna array includes a mixture of isolated and non-isolated antenna elements interleaved in each row and each column of the antenna array. Each isolated antenna element is only adjacent to one or two non-isolated antenna elements in each row and each column. Each non-isolated antenna element is only adjacent to one or two isolated antenna elements in each row and each column. By interleaving the isolated and non-isolated antenna elements in each row and column of the antenna array, it is possible to reduce a number of antenna isolators, thus helping to reduce cost and footprint of the radio node. Further, by using a combination of antenna isolators and simplified digital pre-distortion (DPD) actuators in association with the interleaved antenna array, the radio node is able to satisfy stringent radio frequency (RF) performance requirements.