Disclosed are systems, methods, and non-transitory computer-readable media for cryptography using different sized symbol sets. To protect against a brute force or other similar type of attack, multiple symbol sets having different sizes can be used for encrypting/decrypting data. For example, different portions of the data (e.g., data blocks representing multiple symbols, set of bits representing a single symbol) may be encrypted/decrypted using different symbol sets that include different numbers of unique symbols. Using different sized symbol sets adds additional complexity to the encryption process, thereby greatly increasing the difficulty in decrypting the encrypted data with a brute force attack.