Systems and techniques are described for image processing. An imaging system can include an image sensor that captures image data. An image signal processor (ISP) of the imaging system can demosaic the image data. The imaging system can input the image data into one or more trained machine learning models, in some cases along with metadata associated with the image data. The one or more trained machine learning models can output settings for a set of parameters of the ISP based on the image data and/or the metadata. The imaging system can generate an output image by processing the image data using the ISP, with the parameters of the ISP set according to the settings. Each pixel of the pixels of the image data can be processed using a respective setting for adjusting a corresponding parameter. The parameters of the ISP can include gain, offset, gamma, and Gaussian filtering.