A method of and an Artificial Intelligence (AI) system for predicting hemodynamic parameters for a target vessel, in particular of an aorta, as well as to a computer-implemented method of training an AI unit of the AI system are disclosed. A vessel shape model of the target vessel and a corresponding flow profile of the target vessel are received. At least one hemodynamic parameter is predicted by the AI unit based on the received vessel shape model and the received flow profile. The AI unit is arranged and configured to predict at least one hemodynamic parameter based on a received vessel shape model and a received flow profile of the target vessel (aorta).