A method for operating a cooling system of a motor vehicle for cooling at least one component, a cooling system of a motor vehicle for cooling at least one component, and a motor vehicle having such a cooling system. The cooling system has a coolant circuit and a refrigerant circuit. The coolant circuit serves for cooling the at least one component and the refrigerant circuit and the coolant circuit are coupled thermally to one another via a heat exchanger. The coolant circuit has a conveying device for conveying a coolant in the coolant circuit. A cooling power of the refrigerant circuit can be regulated. The regulation of the cooling power of the refrigerant circuit is realized in a manner dependent on a return temperature of the coolant and/or on a temporal development of the return temperature of the coolant.