Invention Grant
- Patent Title: Nucleoside derivative and use thereof
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Application No.: US16760781Application Date: 2018-10-31
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Publication No.: US11780874B2Publication Date: 2023-10-10
- Inventor: Yoshihito Ueno , Yusuke Maeda , Ryohei Kajino
- Applicant: YAMASA CORPORATION , National University Corporation Tokai National Higher Education and Research System
- Applicant Address: JP Choshi
- Assignee: YAMASA CORPORATION,NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM
- Current Assignee: YAMASA CORPORATION,NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM
- Current Assignee Address: JP Choshi; JP Nagoya
- Agency: Oliff PLC
- Priority: JP 17211339 2017.10.31
- International Application: PCT/JP2018/040544 2018.10.31
- International Announcement: WO2019/088179A 2019.05.09
- Date entered country: 2020-04-30
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H19/10 ; C12N15/113

Abstract:
A nucleoside that is more practical for RNA pharmaceuticals and other applications and use thereof is represented by formula (1) or (2) below, or a salt thereof:
(In formula (1), R1 represents a hydrogen atom, a hydroxyl group, a hydroxyl group in which a hydrogen atom is substituted by an alkyl group or alkenyl group, or a protected group, and in formula (2), X represents a halogen atom. In formula (1) and formula (2), R2 and R3 may be the same or different, and each represents a hydrogen atom etc., R4 represents NHR7 (in which R7 represents a hydrogen atom etc., and B represent represents any of a purine-9-yl group, 2-oxo-pyrimidin-1-yl group, substituted purine-9-yl group or substituted 2-oxo-pyrimidin-1-yl group).
(In formula (1), R1 represents a hydrogen atom, a hydroxyl group, a hydroxyl group in which a hydrogen atom is substituted by an alkyl group or alkenyl group, or a protected group, and in formula (2), X represents a halogen atom. In formula (1) and formula (2), R2 and R3 may be the same or different, and each represents a hydrogen atom etc., R4 represents NHR7 (in which R7 represents a hydrogen atom etc., and B represent represents any of a purine-9-yl group, 2-oxo-pyrimidin-1-yl group, substituted purine-9-yl group or substituted 2-oxo-pyrimidin-1-yl group).
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