Invention Grant
- Patent Title: Methods of producing bioengineered neuronal organoids (BENOs) and uses thereof
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Application No.: US16621707Application Date: 2018-06-08
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Publication No.: US11781109B2Publication Date: 2023-10-10
- Inventor: Wolfram-Hubertus Zimmermann , Maria Zafeiriou
- Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Universitätsmedizin
- Applicant Address: DE Goettingen
- Assignee: GEORGE-AUGUST-UNIVERSITAET GOETTINGEN STIFTUNG OEFFENLICHEN RECHTS, UNIVERSITAETSMEDIZIN
- Current Assignee: GEORGE-AUGUST-UNIVERSITAET GOETTINGEN STIFTUNG OEFFENLICHEN RECHTS, UNIVERSITAETSMEDIZIN
- Current Assignee Address: DE Goettingen
- Agent Stacey J. Farmer
- Priority: EP 175874 2017.06.13
- International Application: PCT/EP2018/065204 2018.06.08
- International Announcement: WO2018/228948A 2018.12.20
- Date entered country: 2019-12-12
- Main IPC: C12N5/0793
- IPC: C12N5/0793 ; C12N5/079 ; G01N33/50
Abstract:
The present invention relates to the field of in vitro 3D modeling of neural tissues, particularly of the brain. There is the need of developing cell culture models of neural tissue that reflect physiological aspects of neural tissue. The present invention provides methods of producing bioengineered neuronal organoids (BENOs) which form functional neuronal networks. The present invention also relates to uses and applications of the produced BENOs, e.g., in the fields of drug screening and personalized medicine.
Public/Granted literature
- US20200208105A1 METHODS OF PRODUCING BIOENGINEERED NEURONAL ORGANOIDS (BENOS) AND USES THEREOF Public/Granted day:2020-07-02
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