Invention Grant
- Patent Title: CRISPR/Cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
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Application No.: US16821384Application Date: 2020-03-17
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Publication No.: US11781131B2Publication Date: 2023-10-10
- Inventor: Marine Prissette , Matthew Koss , Yu Bai , Brian Zambrowicz
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agency: Alston & Bird LLP
- Agent Yongjin Choi
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/10 ; C12N9/22 ; C12N15/113
Abstract:
Cas-protein-ready tau bio sensor cells, CRISPR/Cas synergistic activation mediator (SAM)-ready tau biosensor cells, and methods of making and using such cells to screen for genetic vulnerability associated with tau aggregation are provided.
Public/Granted literature
- US20200299681A1 CRISPR/CAS DROPOUT SCREENING PLATFORM TO REVEAL GENETIC VULNERABILITIES ASSOCIATED WITH TAU AGGREGATION Public/Granted day:2020-09-24
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