A method for loading an Unmanned Aerial Vehicle with one or more items is disclosed. The method includes positioning one or more items in specific positions within one of the Unmanned Aerial Vehicle and a container configured to be carried by the Unmanned Aerial Vehicle based on a Center of Gravity of each of the one or more items. The method also includes securing the one or more items in the specific positions within the one of the Unmanned Aerial Vehicle and the container to prevent the one or more items from shifting and changing a combined Center of Gravity of the one or more items combined with the one of the Unmanned Aerial Vehicle and the container during a flight of the Unmanned Aerial Vehicle.