An environmental control system of a building including a first building device operable to affect environmental conditions of a zone of the building by providing a first input to the zone. The system includes a second building device operable to independently affect a subset of the environmental conditions by providing a second input to the zone and further includes a controller including a processing circuit. The processing circuit is configured to perform an optimization to generate control decisions for the building devices. The optimization is performed subject to constraints for the environmental conditions and uses a predictive model that predicts an effect of the control decisions on the environmental conditions. The processing circuit is configured to operate the building devices in accordance with the control decisions.