A method and system for determining and resolving network issues impacting application performance in multi-domain networks is disclosed. The method includes obtaining at least one of health and performance data associated with an application and one or more alerts related to fault and/or performance issues associated with the application. The method further includes determining at least one of network faults and performance issues that influence at least one of fault and/or performance issues associated with the application. The method further includes determining one or more underlying network problems that impact performance of the application. The method further includes determining at least one appropriate resolution action to address the one or more underlying network problems, implementing the at least one appropriate resolution action; monitoring an effectiveness of the implementation of the at least one appropriate resolution action; and adapting at least one of rules, parameters, and thresholds.