The present disclosure provides a method and a device in a User Equipment (UE) and a base station for wireless communication. A UE first receives a first signaling and a first downlink signaling, and transmits a first radio signal. Herein, the first signaling comprises scheduling information of the first radio signal, the scheduling information includes at least one of a time domain resource occupied, a frequency domain resource occupied, a MCS, a HARQ process number, a RV or a NDI; the first radio signal comprises M first type sub-signal(s) and a second type sub-signal, the M first type sub-signal(s) carries(carry) M first type bit block(s) respectively. The above method can dynamically adjust the number of REs occupied by uplink control information on an uplink physical layer data channel so as to control the transmission reliability of the uplink control information in a flexible manner.