A quantum dot display panel and a manufacturing method thereof are provided. The quantum dot display panel includes an array substrate; a luminescent layer disposed on the array substrate; an encapsulation layer disposed on the luminescent layer; and a color filter layer disposed on the encapsulation layer. The color filter layer includes a plurality of pixel areas. Each of the plurality of pixel areas includes a plurality of sub-pixel filter layers. Each of the sub-pixel filter layers is made of a quantum dot material. A color of a light excited by the quantum dot material is the same as a color of the sub-pixel filter layer. An upper surface of at least one of the sub-pixel filter layers forms a concave structure. The quantum dot display panel provided by the embodiment of the present disclosure enhances the light extraction rate and the display effect of the quantum dot display panel.