Audio operating systems and related systems, methods, and devices are disclosed. A portable electronic accessory includes a microphone to receive audio inputs, a speaker to provide audio outputs, and control circuitry including a cellular data radio circuit and an application processor. The cellular data radio circuit is configured to communicate with a cloud server through a cellular data network. The application processor is configured to execute at least a portion of an audio operating system. The audio operating system is configured to host audio software applications provided by the cloud server. The audio software applications are configured to operate free from graphical user interface elements based at least in part on the audio inputs and the audio outputs. The cloud server includes one or more data storage devices including software application code for audio software applications to be hosted by an audio operating system (OS) of the portable electronic accessory.