A system and method for making an anti-scatter grid device is provided. The method may include providing a mold including one or more orientation structures arranged in first positions. The method may also include placing a plurality of plates including a first material into at least one of the orientation structures, and injecting a second material into a first cavity in the mold formed by the plurality of plates and the orientation structures. The method may further include separating the plurality of plates and the hardened second material from the mold to generate a first module.