The disclosed embodiments include a software-defined security (SDS) service that can monitor runtime behavior of a network of nodes of a wireless network and detect anomalous activity indicating contamination of the network of nodes, where the contamination includes unauthorized instructions designed to damage or interrupt a function of the network of nodes. The SDS service can dynamically coordinate a blacklist and a whitelist, where the blacklist includes an indication of contaminated assets and the whitelist includes an indication of non-contaminated assets. The contaminated assets are isolated with a cleanroom environment, where the security resources sanitize the contaminated assets. Then, indications of the decontaminated assets are moved from the blacklist to the whitelist, and the use of the security resources are dynamically adjusted according to a load ratio between the whitelist and the blacklist.