Aspects relate to time-interleaving of code block groups (CBGs) of a transport block. Some deployments can include configuring a downlink transmission to a scheduled entity that overlaps in time with an uplink transmission from the scheduled entity when the scheduled entity is operating in a full-duplex mode. CBGs may be time-interleaved to accommodate and/or mitigate interference between downlink and uplink transmissions. The modulation and coding scheme (MCS) of the transport block can further be adjusted to accommodate and/or mitigate interference between the downlink and uplink transmissions. Techniques discussed herein can be used at various nodes, components, and/or devices in a wireless network (e.g., UEs, BSs, CUs, RUs, DUs, etc.). Other aspects, features, and embodiments are also claimed and described.