The present disclosure provides a gesture operation method, apparatus, device and medium. The method includes: obtaining depth information of a user hand; determining space coordinates of a virtual hand corresponding to the hand in a virtual space based on the depth information; binding trackballs to the virtual hand based on the space coordinates, which includes binding a palm ball to a palm position of the virtual hand, and binding at least one fingertip ball to at least one fingertip position of the virtual hand, a volume of the palm ball being greater than the at least one fingertip ball; and performing a corresponding operation in the virtual space based on a straight-line distance between the at least one fingertip ball and the palm ball.