Disclosed is a device for stimulating the tracheobronchial air of a patient suffering from an obstructive ventilatory disorder and able to modify the rheology of his tracheobronchial mucus, which includes a negative pressure generator, a physiological interface able to interface the device with the patient's respiratory apparatus, a connection pipe connecting the physiological interface to the negative pressure generator, and a control circuit capable of controlling the negative pressure generator, during the passive expiration phase, for the application of a succession of alternation of negative pressure and venting impulses with a determined frequency and a duty cycle determined during a first part of an expiration cycle and then a second frequency and a second duty cycle during a second part of the expiration cycle and to reiterate a defined number of expiration cycles.