System and method embodiments are provided for signaling reference signals and Channel State Information (CSI) feedback for wireless communications. An embodiment method implemented by a user equipment (UE) for wireless communications measurements and CSI feedback includes receiving, from a network, at least one of a first index that indicates a corresponding non-zero-power CSI reference signal (CSI-RS) resource, a second index that indicates a corresponding zero-power CSI-RS resource, a third index that indicates a corresponding CSI-RS resource for interference measurement, and a fourth index that indicates a corresponding channel quality indicator (CQI) report configuration. The method also includes receiving, from the network, at least one of a fifth index that indicates a corresponding periodic CQI report in accordance with the CQI report configuration indicated by the fourth index, and a sixth index that indicates a corresponding aperiodic CQI report in accordance with the CQI report configuration indicated by the fourth index.