A molding tool for forming a non-pneumatic tire includes a wheel portion cavity, a tread ring portion cavity, and a plurality of spoke cavities extending between the wheel portion cavity and the tread ring portion cavity. At least a subset spoke cavities within the plurality of spoke cavities include at least one of a non-uniform thickness, a non-uniform width, and a non-uniform surface. Also, the molding tool can include a conformal thermal control channel, e.g., a conformal cooling channel and/or a conformal heating channel, proximate to at least one mold cavity.