A waste disposal system has a waste disposal device and cassette having a length of flexible film. The cassette has a lower surface and a guide feature enabling the cassette to rotate within the upper housing of the pail, maintain a substantially stationary position within the upper housing of the pail, or combinations thereof. The waste disposal device has a guide member that engages the guide feature of the cassette. The waste disposal device has a cassette housing and a sealing mechanism. One of the housing and sealing mechanism, and the cassette, rotate with respect to the other, either directly or indirectly.