Scanning systems and related methods are provided. The scanning systems and methods may be computed tomography (CT) based scanning systems and methods. According to some aspects, the scanning systems have a reduced size compared to conventional scanning systems and may have similar throughput to some conventional scanning systems. According to some aspects, the scanning systems are reconfigurable into at least two scanning arrangements. Reduced size and/or reconfigurable scanning systems can allow an operator to dispose a scanning system in an environment that would not accommodate a conventional scanning system. Accordingly, the scanning systems described herein can provide enhanced security in some environments.