Real-time prevention of computerized event manipulation through the use of Artificial Intelligence (AI)-assisted quantum computing. Determine, at an event request time, if the event is being manipulated and/or is part of a manipulation scheme and, if so, prevent the event from being initiated. A classical computing platform analyzes a batch of historical events using AI including machine learning classification algorithms to result in a manipulation indicator for each of the historical events. A quantum computing platform converts each of the historical events in the batch to a qubit sequence based on attributes associated with the events. The qubits are entangled with qubits of a primary qubit sequence and maintained an entangled list. When an event is requested, attributes associated with the pending event are communicated to the quantum computing platform, which transforms/converts the pending event to the primary qubit sequence based on the attributes associated with the pending event.