Techniques for improving adaptive interference cancellation (AIC) using cascaded AIC algorithms are described. To improve an accuracy of detecting speech, a device may perform a first stage of AIC to generate isolated audio data and may generate speech mask data indicating time windows when speech is detected in the isolated audio data. Based on the speech mask data, the device may perform second AIC to generate output audio data, with adaptation of the adaptive filter enabled when the speech is not detected and disabled when the speech is detected. Thus, the first AIC improves the accuracy with which the device detects that speech is present and the second AIC reduces distortion in the output audio data by not updating filter coefficient values when the speech is present. The first AIC may use playback audio data, microphone audio data or beamformed audio data as reference signals.