A self-adjusting device configured to be placed in contact with tissue/organ and apply mechanical force to the tissue/organ to achieve an improvement of functioning of the tissue/organ. The self-adjusting capabilities can be carried out by three functional subsystems that can be packaged either in a single, integrated system or in separate modules. A sensing subsystem senses the tissue/organ and sends at least one type of sensing signal characteristic of functioning of the tissue/organ to a controlling subsystem. The controlling subsystem processes the signal with an algorithm to determine if a configuration of the device needs to be changed or a force applied to the tissue/organ needs to be changed. An actuating subsystem can be controlled by the controlling subsystem to affect the configuration/force change when needed. A feedback loop is provided to keep the controlling subsystem up to date as to the state of the actuating subsystem.