A vehicle frame structure capable of achieving light weight, improving structural rigidity, and providing a good casting and forming effect is provided. The vehicle frame structure includes a pair of side portions and a connecting portion. The pair of side portions extends in a vehicle front-rear direction and is mounted on a vehicle body. The connecting portion is arranged as an elongated structure having a pair of long sides and is connected between the pair of side portions. The pair of side portions and the connecting portion are integrally formed by casting through injecting of molten metal from one side of the pair of long sides of the connecting portion. The connecting portion has a film surface connecting the pair of side portions and has a plurality of elongated holes extending radially from the center of the film surface towards the other side of the pair of long sides.