Invention Grant
- Patent Title: Compounds useful as inhibitors of isoprenylcysteine carboxyl methyltransferase
-
Application No.: US16646693Application Date: 2018-09-12
-
Publication No.: US11834430B2Publication Date: 2023-12-05
- Inventor: Soo Yei Ho , Anders Poulsen , Sum Wai Eldwin Tan , Shi Hua Ang , Thomas Hugo Keller
- Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Applicant Address: SG Singapore
- Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Current Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- Current Assignee Address: SG Singapore
- Agency: MARSHALL, GERSTEIN & BORUN LLP
- Priority: SG 201707444W 2017.09.12
- International Application: PCT/SG2018/050466 2018.09.12
- International Announcement: WO2019/054944A 2019.03.21
- Date entered country: 2020-03-12
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D231/12 ; C07D233/12 ; C07D249/08 ; C07D401/12 ; C07D401/14 ; A61P35/00 ; C07D233/06 ; C07D233/60 ; C07D261/08 ; C07D277/24 ; C07D403/12
Abstract:
The present invention relates to compounds of general Formula (I), and/or tautomers, enantiomers, solvates, hydrates, and pharmaceutically acceptable salts thereof. The present invention also relates to compounds of Formula (I) for use in therapy, methods of treating isoprenylcysteine carboxyl methyltransferase (ICMT) related disorders or uses of compounds of Formula (I) in the manufacture of a medicament for the treatment of ICMT-related disorders, wherein the disorder is cancer and/or progeria. The present invention further relates to processes for synthesizing compounds of Formula (I).
Public/Granted literature
- US20210130317A1 Compounds Useful as Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase Public/Granted day:2021-05-06
Information query
