- Patent Title: Processes for preparation of soluble guanylate cyclase stimulators
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Application No.: US16315221Application Date: 2017-07-06
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Publication No.: US11834444B2Publication Date: 2023-12-05
- Inventor: Song Xue , Vishnu Vardhan Reddy Karnati , Robert C. Livingston , Timothy Claude Barden , Wayne C. Schairer
- Applicant: Cyclerion Therapeutics, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Cyclerion Therapeutics, Inc.
- Current Assignee: Cyclerion Therapeutics, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: McCarter & English, LLP
- Agent Xin Zhang; Zhongyu “Alex” Wang
- International Application: PCT/US2017/040817 2017.07.06
- International Announcement: WO2018/009602A 2018.01.11
- Date entered country: 2019-01-04
- Main IPC: C07D413/14
- IPC: C07D413/14 ; C07D413/04 ; C07D261/08 ; C07D261/18 ; A61F9/00 ; A61P43/00 ; A61K31/506 ; C07C237/06 ; C07C209/00 ; C07C231/12 ; C07C231/14 ; C07C235/06

Abstract:
The present disclosure relates to novel processes for the preparation of compounds useful as stimulators of soluble guanylate cyclase (sGC). These processes are amenable to large scale preparation and produce stable 3-(2-pyrimidinyl)pyrazoles of Formula (I), including Compound (I), Compound (IA) and Compound (IB), in high purity and yields. The present invention has the additional advantage of facile reaction conditions, amenable to scale up for large scale manufacturing. The disclosure also provides novel intermediates useful in the preparation of said compounds.
Public/Granted literature
- US20210284632A1 NOVEL PROCESSES FOR PREPARATION OF SOLUBLE GUANYLATE CYCLASE STIMULATORS Public/Granted day:2021-09-16
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