Invention Grant
- Patent Title: Biparatopic FR-alpha antibodies and immunoconjugates
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Application No.: US17838016Application Date: 2022-06-10
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Publication No.: US11834498B2Publication Date: 2023-12-05
- Inventor: Olga Ab , Neeraj Kohli , Thomas Chittenden , Julianto Setiady
- Applicant: ImmunoGen, Inc.
- Applicant Address: US MA Waltham
- Assignee: ImmunoGen, Inc.
- Current Assignee: ImmunoGen, Inc.
- Current Assignee Address: US MA Waltham
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K31/5365 ; A61P35/00 ; A61K47/68

Abstract:
The present disclosure provides biparatopic antibodies comprising polypeptides that bind to folate receptor alpha (FRα) compositions comprising such biparatopic antibodies. In a specific aspect, the biparatopic antibodies bind to FRα and modulate FRα activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering a biparatopic antibody that specifically binds to FRα and modulates FRα activity.
Public/Granted literature
- US20230085779A1 BIPARATOPIC FR-ALPHA ANTIBODIES AND IMMUNOCONJUGATES Public/Granted day:2023-03-23
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