According to various embodiments, a system and method for processing an image of a biological specimen stained for a presence of at least one lymphocyte biomarker is disclosed. The system and method are configured to detect lymphocytes in the image and compute a foreground segmentation mask based on the lymphocytes detected within the image. Outlines of the detected lymphocytes are identified in the image by filtering the image with the computed foreground segmentation mask. A shape metric may be derived for each of the detected lymphocytes based on the identified lymphocytes outlines. The derived shape metric may be associated with location information for each of the detected lymphocytes and a value of each of the derived shape metric may be compared to a predetermined threshold value. A predictive cell motility label may be assigned to each of the detected lymphocytes based on the comparison.