The application discloses a main-machine interaction method and system, a computer device, and a storage medium. The method includes: an interaction end collects user information including biological sample information and preprocesses and filters the user information, and sends the preprocessed information to a central server; the central server assigns a biological recognition task and distributes the biological recognition task to a computing server; the computing server extracts biological characteristics from the biological sample information according to the biological recognition task, and returns obtained extraction results to the central server; the central server combines the extraction results to get a processing result; the processing result is returned to the interaction end; the interaction end responds to the processing result to complete a man-machine interaction with the user.