Invention Grant
- Patent Title: Systems and methods for the treatment of hemoglobinopathies
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Application No.: US16569336Application Date: 2019-09-12
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Publication No.: US11851690B2Publication Date: 2023-12-26
- Inventor: Jennifer Leah Gori , Luis A. Barrera , Edouard Aupepin De Lamothe-Dreuzy , Jack Heath
- Applicant: EDITAS MEDICINE, INC.
- Applicant Address: US MA Cambridge
- Assignee: EDITAS MEDICINE, INC.
- Current Assignee: EDITAS MEDICINE, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Perkins Coie LLP
- Agent Courtney Prochnow
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C12N9/22 ; C12N15/11 ; A61K31/7105 ; A61K38/46
Abstract:
Genome editing systems, guide RNAs, and CRISPR-mediated methods are provided for altering portions of the HBG1 and HBG2 loci, portions of the erythroid specific enhancer of the BCL11A gene, or a combination thereof, in cells and increasing expression of fetal hemoglobin.
Public/Granted literature
- US20200157515A1 SYSTEMS AND METHODS FOR THE TREATMENT OF HEMOGLOBINOPATHIES Public/Granted day:2020-05-21
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