- Patent Title: Replication stress response biomarkers for immunotherapy response
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Application No.: US16978758Application Date: 2019-03-06
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Publication No.: US11851712B2Publication Date: 2023-12-26
- Inventor: Daniel McGrail , Shiaw-Yih Lin , Patrick Pilie , Eric Jonasch , Curtis Chun-Jen Lin
- Applicant: Board of Regents, The University of Texas System
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Parker Highlander PLLC
- International Application: PCT/US2019/020921 2019.03.06
- International Announcement: WO2019/173456A 2019.09.12
- Date entered country: 2020-09-07
- Main IPC: C12Q1/6886
- IPC: C12Q1/6886 ; C12Q1/6813
Abstract:
Methods for increasing immune therapy response and predicting likelihood of cancer metastasis by analyzing the expression of genes associated with replication stress response. In some aspects, cancers are treated with immune checkpoint inhibitors and/or MEK inhibitors. Methods for selecting patients by analyzing the expression of genes associated with a defect in replication stress response are also provided.
Public/Granted literature
- US20210130906A1 REPLICATION STRESS RESPONSE BIOMARKERS FOR IMMUNOTHERAPY RESPONSE Public/Granted day:2021-05-06
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