A lettuce cultivar, designated Apollo Creed, is disclosed. The invention relates to the seeds, plants, and plant parts of lettuce cultivar Apollo Creed and to methods for producing a lettuce plant by crossing cultivar Apollo Creed with itself or another lettuce cultivar. The invention further relates to methods for producing a lettuce plant containing in its genetic material one or more transgenes and to the transgenic lettuce plants and plant parts produced by those methods. This invention also relates to lettuce cultivars or breeding cultivars and plant parts derived from lettuce cultivar Apollo Creed, to methods for producing other lettuce cultivars, lines or plant parts derived from lettuce cultivar Apollo Creed and to the lettuce plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid lettuce seeds, plants, and plant parts produced by crossing cultivar Apollo Creed with another lettuce cultivar.