Disclosed herein are devices and methods of using a mobile or wearable device for the acquisition and spatial filtering of ECG signals from an electrode array. One variation of a mobile or wearable device comprises an array of electrodes, one or more reference electrodes, and a controller in communication with the electrodes. In one example, the one or more reference electrodes are located on a wrist-worn device (e.g., a watch), and the electrode array is located on an accessory device that may be contacted with a fingertip. One variation of a spatial filtering method comprises identifying the electrodes that have high levels of noise and excluding the ECG signals from those electrodes from further analyses. In another variation, a method of spatial filtering comprises identifying electrodes with low levels of noise and including only the ECG signals from those electrodes in further analyses.