Invention Grant
- Patent Title: Hydrophobic Auristatin F compounds and conjugates thereof
-
Application No.: US16968749Application Date: 2019-02-20
-
Publication No.: US11857565B2Publication Date: 2024-01-02
- Inventor: Svetlana O. Doronina , Philip Moquist
- Applicant: SEAGEN INC.
- Applicant Address: US WA Bothell
- Assignee: SEAGEN INC.
- Current Assignee: SEAGEN INC.
- Current Assignee Address: US WA Bothell
- Agency: MORRISON & FOERSTER LLP
- International Application: PCT/US2019/018825 2019.02.20
- International Announcement: WO2019/164987A 2019.08.29
- Date entered country: 2020-08-10
- Main IPC: A61K31/74
- IPC: A61K31/74 ; A61K47/64 ; A61K38/02 ; A61K47/65
Abstract:
Ligand Drug Conjugates of hydrophobically-modified auristatin F compounds that exhibit cytotoxic activities towards targeted cells, including abnormal cells such as cancer cells, that are MDR+ while also exhibiting bystander activities towards nearby cells having lower expression of the moeity targeted by the Conjugate.
Public/Granted literature
- US20210008099A1 HYDROPHOBIC AURISTATIN F COMPOUNDS AND CONJUGATES THEREOF Public/Granted day:2021-01-14
Information query
