An auto-feed pipe cleaner comprises a take-up unit comprising a wire drum and a spring wire; and a feed unit comprising a telescopic tube, a feeder for disposing a movable bearing and two fixed bearings, a tube handle disposed inside the telescopic tube and embedded with the feeder, and an elastic plate embedded inside the feeder. A user holds the telescopic tube with one hand, and holds a small handle of the wire drum with another hand to rotate the wire drum forwardly or reversely and drive the spring wire to rotate forwardly or reversely, and pushes the telescopic tube forward so that the movable bearing is pressed downward by the elastic plate and actuated with the fixed bearings to start feeding the spring wire or taking up the spring wire into the wire drum. When the telescopic tube is pulled backward, the movable bearing is not actuated.