A powder compaction device is disclosed. The device has a drive motor operable connected to a compaction rod that moves through a loading platform to a cartridge holding platform. A powder loading station is positioned below the loading platform and above the cartridge holding platform. The compaction rod moves through the powder loading station, which loads a predetermined volume of propellant powder into one or more reliefs defined in the compaction rod. The cartridge holding platform has a removable cartridge fixture designed to receive an ammunition cartridge to be loaded and compacted with propellant powder. The propellant powder is released into the cartridge fixture from the reliefs as the compaction rod passes a funnel defined at an upper end of the fixture. After releasing the powder, the compaction rod continues into an interior chamber of the fixture to compact the powder contained therein.