Invention Grant
- Patent Title: Classification of epigenetic biomarkers and/or DNA conformational superstructures via use of atomically thin nanopores
-
Application No.: US16850575Application Date: 2020-04-16
-
Publication No.: US11860123B2Publication Date: 2024-01-02
- Inventor: Jean-Pierre Leburton , Lav Raj Varshney , Aditya Sarathy , Nagendra B. Athreya
- Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Applicant Address: US IL Urbana
- Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Current Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Current Assignee Address: US IL Urbana
- Agency: Guntin & Gust, PLC
- Agent Matthew Tropper
- Main IPC: G01N27/447
- IPC: G01N27/447 ; C12Q1/6874 ; G01N33/487 ; B82Y5/00

Abstract:
An apparatus comprising: a membrane with a first side, a second side, and a pore that extends through the membrane; a processing system including a processor; and a memory that stores executable instructions that, when executed by the processing system, facilitate performance of operations, the operations comprising: electronic sensing of an electrical characteristic associated with a translocation of a test DNA through the pore, resulting in a sensed electrical characteristic; comparing the sensed electrical characteristic with a plurality of reference electrical characteristics, wherein each of the plurality of reference electrical characteristics is associated with a respective one of a plurality of reference features, and wherein the comparing results in a comparison result; and determining, based upon the comparison result, with which of the plurality of reference features a feature of the test DNA corresponds. Additional embodiments are disclosed.
Public/Granted literature
Information query