A device and methods for cleaning an end of a fiber optic cable including a cleaning cartridge system for dispensing and usage monitoring of fiber end face cleaning fabric. The cleaning cartridge system includes a spool of cleaning fabric; an actuator that drives a fabric advance roller; a pressure sensor that detects when a fiber end face is in contact with fabric and outputs a contact-indicating signal; an internal control circuit that drives the actuator to advance the cleaning fabric in time-relation to the contact-indicating signal; and an external controller that determines proper advance of the cleaning fabric and consumption of the cleaning fabric over time. Methods of maintaining low loss physical fiber-optic connections in an automated cross-connect system use the cleaning device and methods.